SPERMINE and SPERMIDINE (S/S) are polyamines. You may have never heard of these, but soon you will. These organic molecules are the source of intense drug research for a new development of medical treatment for at least one hundred diseases. These include Poly-Cystic Ovary Disease, Sexual Dysfunction, Pre-Menopause Syndrome, Infertility, Menopause, Andropause, and Hormonal Related Skin Conditions such as Acne and Hirsuitism. There are currently fifteen proposed medicines now in front of the FDA for product approval. A Canadian company has EroxilR, which is now on the market as a natraceutical and is showing some promising results with sexual improvement. To date, however, there is no U.S. company marketing S/S or any of the derivatives thereof. However, natural Spermine has been available for three hundred years and in the last two has been purified along with spermidine and given to several thousand patients in America with good success for varying maladies. S/S is considered a natraceutical and needs no formal FDA approval only expert guidance as to their use which is different for the artificial chemicals that are classified as drugs or pharmaceuticals.
Spermine and Spermidine, are the active ingredients in BODY EQUILIBRIUM, which are derived from naturally occurring phytochemicals found in corn, cucumber, oats, and radishes. The proposed study is to better evaluate the products efficacy. It safety is already know and is considered GRAS (Generally Regarded As Safe) by the FDA. A polymine of which S/S are the prototypes are organic compounds having two or more primary amino groups (NH2 ). The name Spermine reflects its discovery in human semen in 1678, by Anton Van Leeuwenhoek, who refined the microscope so he could see particles and even living organisms in living tissue. Spermidine and Putrescine, a close relative, were identified in the early 1900s; the latter was so named in that this chemical has the odor of putrefying flesh. More than 300 years since their discovery, Polymines are attracting much interest from researchers because of their wide spectrum of physiological functions. Polyamines, such a S/S and putrescine, are ubiquitous compounds that are produced by almost all living organisms, including plants, animals, fungi and bacteria. Polyamines are multifunctional and guide many cellular functions. They are essential elements for cellular and tissue growth and regeneration and hence, play a large role in health maintenance and aging. Spermine and spermidine are the two main polyamines in our tissue and play a role as adaptagens to bring the body into equilibrium. They are present in plants (food) and our bodies naturally synthesize them from dietary amino acids such as ornithine and methionine. Agmatine, a close relative of S/S is produced by decarboxylation of arginine and figures into the production of Nitric Oxide, which also has a positive effect on health.
If cellular polyamine synthesis is inhibited, cell growth is stopped or severely retarded. However, consumption and internal synthesis of polyamines restores the growth of tissue. Most of our cells have a membrane polyamine transporter system that facilitates the internalization of exogenous polyamines. This system is highly active in rapidly proliferating cells. As hinted above, polyamines are the target of synthetic chemicals (drugs) for the treatment of cancer, parasites, bacterial infection, and hormonal imbalances. They enhance the permeability of the blood–brain barrier and may improve psychiatric problems such as depression and even schizophrenia. S/S have been extensively studied in skin, hair growth, female fertility, fat deposits, pancreatic integrity, and regenerative growth in mammals. They are also free radical scavengers.