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Pentoxifylline (PTX)

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April 15, 2014

Pentoxifylline -PTX is a Rheologic antiinflamatory drug introduced in the US 30 years ago for the treatment of peripheral vascular disease hich is the only FDA indication. It is still used throughout the world but has all but been forgotten here. Other than in America PTX has many other usages including cerebrovascular disease, vaso-occlusive crises of sickle cell disease, high altitude sickness, asthenozoospermia (but not oligospermia), acute and chronic hearing disorders, eye circulation, skin ulcers, CAD, CHF, and Alcoholic Hepatitis.

The blood flow or rheologic properties of blood is greatly enhanced by the drug. Thus defective regional microcirculation is improved by increasing red blood cell deformability, reducing blood viscosity and decreasing platelet aggregation thus preventing thrombus formation.

Now that the potent anti-inflammatory properties of PTX were discovered, it has a much expanded role in treating many other diseases. PTX modulates TNF-α signaling, which contributes to the considerable suppression of inflammation. In a recent trial, 400 mg of pentoxifylline taken twice-daily significantly suppressed hs-CRP, fibrinogen, and TNF-α levels in patients with chronic kidney disease also renal function improved. In patients with HIV-related vascular dysfunction, PTX lessened leukocyte adhesion – a process that contributes to cardiovascular disease by allowing inflammatory cells to infiltrate the endothelial lining of blood vessels. Given by IV-infusion, pentoxifylline lowered TNF-α levels and pain intensity following surgical removal of kidney stones. This drug decreass metastasis of cancer by also decreasing the “stickiness” of the cells leaving the tumor so they will not stick on other tissue as they break off and enter the circulation.

Extensive open and placebo-controlled studies have shown that pentoxifylline 600 to 1200 mg/day for at least 6 weeks is associated with subjective and objective improvements in 60 to 100% of patients with peripheral vascular disease. The most commonly assessed clinical parameter, walking distance, is usually improved by about 100%, although much greater improvements have also been documented. Other parameters which have been clearly improved include lower limb rest pain, paraesthesia, muscle blood flow, cramps and leg ulcers.

It is well tolerated when administered as the conventional controlled release formulation, gastrointestinal symptoms – usually nausea (about 3%) being the most common complaint. Costing $30/month, it is almost a best buy in treating some diseases and protecting ones health i.e. lowering HsCRP and fibrinogen. 400mg three times a day with meals to avoid nausea is the dose.

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The Season to Be Sneezing

April 7, 2014

Sub Lingual Immuno Therapy or SLIT is less expensive safer, and almost equally as effective than SCIT (Sub Cutaneous Immuno Therapy). SLIT involves placing drops or tablets of an allergen under the tongue of a patient rather than by injection….

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Tale of Two Docs

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An Unwise Choice

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Breast Thermography

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CHOP LIVER

February 28, 2014

NAFLD CAN NASH UP YOUR LIVER Non-Alcoholic Fatty Liver Disease (NAFLD) is a series of progressive liver abnormalities characterized by excessive fat accumulation in the liver causing inflammation. NAFLD actually encompasses a spectrum of conditions associated with lipid deposition in…

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LOST WORDS

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Silent but devastating is the sudden disconnection of a memory bank from its retrieval mechanism. Anomic aphasia (anomia) or tip-of-the-tongue phenomenon, sometimes called presque vu, is the failure to obtain a word from memory. This is characterized by the inability…

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VICIOUS VISCOUS

February 14, 2014

Do not let your blood run like molasses in January, which is medically speaking increase blood VISCOSITY. This is the only biological parameter that has been linked to all of the major cardiovascular risk factors. Blood viscosity is defined “as…

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