The JAMA Article (Nov. 5, 2013) – “Testosterone Treatment
 Causes Heart Attacks” gave me concern. Hopefully the media’s portrayal of this flawed study will not discourage aging men from properly restoring their testosterone levels. In order to protect against heart…

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  • Scientific Medicine

    Vitamin K gives protection against arterial calcification, Alzheimers, bone loss, cancer, and even aging! Although discovered in 1929, both Edward Adelbert Doisy (who died in1986), an American biochemist, along with his Danish colleague, Henrik Dam received the Nobel Prize in…

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  • Traditional And Unique Therapy

    The brain uses mainly glucose for its fuel, but works far better when fed ketones. Ketogenic diets have been used in medicine since 1924 initially to prevent seizures, and recently to treat degenerative neurologic diseases such as Multiple Sclerosis, ALS,…

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  • Difficult Diagnosis

    An example of a difficult diagnostic dilemma is Lectin Intolerance. Lectin not to be confused with Leptin or Lecithin)occur ubiquitously in nature. They are sugar-binding proteins in both animal and plants. The prototypic lectin is GLUTEN. Lectins aggregates to the cell…

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October 20, 2014

Ebola is a disease of humans, monkeys and fruit eating bats. These three species cannot make their own Vitamin C, a phenomenon of more than interest of which we will discuss later. Initially discovered in 1976 on the banks of the Ebola river in the Congo (now Zaire) which gives the virus its name. Signs and symptoms typically start between two days and three weeks after contracting the virus, with a fever, sore throat, muscle pain and headaches. Then, vomiting, diarrhea and rash follows, along with progressive decreased function of the vital organs. Around this time, the patient begins to bleed both internally and externally. Death, which occurs in 40 to 85%, is typically six to sixteen days after symptoms appear. In the past the treatment has been supportive till the patient can build up enough antibodies to overcome the virus before being overcome themself.

The major problem is immune system dysregulation causing a cytokine (cellular chemical messenger) storm, referred to as SIRS (Systemic Inflammatory Response Syndrome). This is an inflammatory state affecting the whole body, the response of the immune system to an overwhelming infection. The Ebola viral infection in this case, and its propensity to attack blood vessel lining, leading to their leaking.

Ebola is a lipid-enveloped virus and cannot manufacture a protective enzyme called catalase. Therefore Ebola has little defense against increased oxidation stress. Catalase is a common enzyme found in nearly all living organisms. It is a very important in protecting the cell from oxidative damage by reactive oxygen species usually caused by its metabolism but also with medical intervention. Amongst other characteristics it catalyzes the decomposition of hydrogen peroxide to water and oxygen. Catalase has one of the highest turnover numbers of all enzymes; one catalase molecule can convert millions of molecules of hydrogen peroxide to water and oxygen each second.

In addition to other novel therapies that include the now available cardiac drugs (Amiodarone, Dronedarone and Verapamil) we should consider oxidative therapy. The rationale is based on the research and clinical experiences of my late colleague from Oklahoma City, Charles H. Farr, MD, PhD (1927-1998). I had the pleasure of spending several weekends with him and his wife Skoshi. He was true champion of this therapeutic method, is often referred to as the “Father of Oxidative Medicine.” In the early 80’s he was elected as a candidate for a Nobel Prize. Others such as Drs. Frank Shallenberger and Robert Rowen have since advocated the use of intravenous infusions of hydrogen peroxide for a multitude of indications to include the control of this epidemic. In fact, Dr Rowen, has been invited by the President of Sierra Leone to treat infected medical workers and to train health care personnel in the application of oxidative therapies. He will be working with approximately 120 M.D.’s from Cuba where more research on oxidative therapies to kill viruses has been done than any other country in the world.

Admittedly, oxidative therapies to include, intravenous Ozone and Ultraviolet light have been around since the 1920′s. Later, these oxidative therapies were used to cure polio. In the last thirty years Vitamin C which also is pro-oxidant has been shown to kill this virus. High-doses (50-100 grams) increase H2O2, both in the extracellular space near cells and inside the cells, by way of the iron driven Fenton reaction. This oxidation factor is strongly toxic for most bacteria, viruses and cancer cells because they lack the catalase enzyme, which is required to metabolize H2O2. We at Intergrations have been using these therapies for a variety of diseases as has other forward thinking doctors. I hope we will never need to do this for Ebola, but we are ready.


Too Much Exercise Is Bad


October 5, 2014

IntensityJcurveCardiac overuse injury can occur with too much or over aggressive aerobic/cardio exercise. Typically there is a rising straight line if more is better, but if a J shape curve is emblazoned then this is unhealthy. J is not for my first name but the well known concept that too much of a “good thing is bad” In medicine, the ‘J-curve’ refers to a graph or a plot in which the x- or horizontal axis measures either of two treatable symptoms (blood pressure or blood cholesterol level) while the y-or vertical axis measures the chance that a patient will develop cardiovascular disease (CVD). It is well known that high blood pressure or high cholesterol levels increase a patient’s risk. What is less well known is that plots of large populations against CVD mortality often takes the shape of a J curve, which indicates that patients with very low blood pressure and/or low cholesterol levels are also at increased risk. The curve falls at the outset and eventually rises to a point higher than the starting point, inscribing the letter J Hippocrates stated that “Everything in excess is opposed to nature”.

My colleague, James O’Keefe published an editorial in the MAYO CLINIC PROCEEDINGS that exercise in moderation is good for promoting health and longevity but high-intensity endurance training programs are not! Thirty minutes of regular vigorous running enhances health and wellbeing. Studies suggest that extreme exercise causes elevations in cardiac blood test that indicate not only the heart not working so well (myocardial dysfunction), but actual heart damage (microinfarction with subsequent fibrosis).

Zealous athletes have experience with orthopedic overuse injuries such as plantar fasciitis, Achilles tendonitis, shin splints, and patellar chondromalacia. But with the cardiac overuse injury there could be an heart attack, life threatening cardiac rhythms, coronary plaque formation, heart muscle stiffening, plaque rupture, and even sudden cardiac death.

In general exercise does improve heart health, quality of life, and overall longevity. But like a drug, a good doc must have an indication and a contraindication, and an amount. With any treatment establishing a safe and effective dose range is essential. A low dose may not give full benefits, whereas too much does harm.

A weekly cumulative dose of endurance exercise of not more than about 5 hours has been identified in several studies to be the safe upper range for long-term health and life expectancy. High Interval Intensive Training or HIIT for short is recommended four to five times a week. To perform it correctly, you’ll want to raise your heart rate to your anaerobic threshold (become extremely short of breath), and to do that, you have to give it your all for those 20 to 30 second intervals. Recover until your breathing is no longer labored and do it again and again. By aggressively working your skeletal muscle and the cardio-pulmonary organs to fatigue, but not overdoing it you’re stimulating adaptation that will not only improve your anatomic/metabolic capability but also the muscle, heart and lungs.


Garbage Men For Your Brain

September 21, 2014

New research shows a good night’s rest is not just a luxury. It is critical for our brain’s health. Revitalizing,by recouping, repairing, and regrouping is a must for a happy healthy brain. When we sleep our focus on sensory cues,…

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September 14, 2014

Dulces Sueños! It is about time the U.S. Food and Drug Administration approved a new non-benzo sleeping pill. But, Belsomra is a controlled substance (Schedule-IV) because it can be abused or lead to dependence. The drug, Belsomra (suvorexant) will be…

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Safe Versus Dangerous Foods Or DO NOT EAT CRAP

September 14, 2014

I have been recommending celery, particularly its seeds for Blood Pressure control and Kale for being extremely nutrient dense without the lousy unneeded calories. Focus on buying certain organic items, while “settling” for others that are conventionally-grown. To do this, familiarizing…

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Choosing Essential Habits

September 14, 2014

Everything we do is based on choice. Not our genetics, past relationships, employment, the economy, the weather, an argument, or the ozone layer. We alone are responsible for every decision and choice we make. If we just avoided the 4…

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Truly Essential?

August 26, 2014

Something Is Fishy In Medicine Scientific research suggests that omega-6 arachidonic acid (AA) in large amounts and the omega-3 docosahexaenoic acid (DHA) in small quantities are the only fatty acids that are truly essential and thus necessary in the diet…

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Not Consensus

August 17, 2014

Great scientific medicine comes from someone who broke with consensus because of their conscience. Such people will usually have scars on their persona, or finances to prove it. In 1847 Dr. Ignaz Semmelweis a Hungarian doctor teaching medicine in Vienna…

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Eye Exercise

August 10, 2014

What has eyes and cannot see? -Potatoes! The eyes believe themselves; the ears believe other people.—German Proverb The only thing worse than being blind is having sight but no vision.—Helen Keller Our eyes need regular exercise in order to keep…

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Wants Versus Needs

July 20, 2014

If a person wants more than they need it causes more stress than the other way around. We do not always have the power to change our needs, but we can for our wants. It is this disparity between wants…

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